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Article

Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers.

Chembiochem : a European journal of chemical biology - 5 Jan 2009

Brucale Marco, Sandal Massimo, Di Maio Selena, Rampioni Aldo, Tessari Isabella, Tosatto Laura, Bisaglia Marco, Bubacco Luigi, Samorì Bruno

Abstract excerpt

Alpha-synuclein (alpha-Syn) is an abundant brain protein whose mutations have been linked to early-onset Parkinson's disease (PD). We recently demonstrated, by means of a single-molecule force spectroscopy (SMFS) methodology, that the conformational equilibrium of monomeric wild-type (WT) alpha-Syn shifts toward beta-containing structures in several unrelated conditions linked to PD pathogenicity. Herein, we...

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PMID: 19067456
DOI: 10.1002/cbic.200800581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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