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Article

Somatic hypermutation of an immunoglobulin mu heavy chain transgene.

The Journal of experimental medicine - 1 Feb 1993

Sohn J, Gerstein R M, Hsieh C L, Lemer M, Selsing E

Abstract excerpt

We have analyzed somatic hypermutation of an immunoglobulin (Ig) heavy chain transgene. Hybridomas expressing the transgene were produced from immunized transgenic mice and transgene copies were sequenced to assay for mutation. In two IgM-producing hybridomas, as well as in several IgG-producing hybridomas, mutations were found in the VDJ region of the transgene. In the IgM-producing hybridomas, both mutated and...

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Identifiers

PMID: 8426117
DOI: 10.1084/jem.177.2.493
PMCID: PMC2190889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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