Somatic hypermutation of an immunoglobulin mu heavy chain transgene.

doi:10.1084/jem.177.2.493

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Article

Somatic hypermutation of an immunoglobulin mu heavy chain transgene.

The Journal of experimental medicine - 1 Feb 1993

Sohn J, Gerstein R M, Hsieh C L, Lemer M, Selsing E

Abstract excerpt

We have analyzed somatic hypermutation of an immunoglobulin (Ig) heavy chain transgene. Hybridomas expressing the transgene were produced from immunized transgenic mice and transgene copies were sequenced to assay for mutation. In two IgM-producing hybridomas, as well as in several IgG-producing...

Topics

Amino Acid Sequence
Animals
Base Sequence
Genes, Immunoglobulin
Immunoglobulin Variable Region
Immunoglobulin gamma-Chains
Immunoglobulin mu-Chains
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

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