Article
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
Nature - 1 Jan 2000
O'Brien R L, Brinster R L, Storb U
Abstract excerpt
Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low. Some evidence for the idea that mutations are introduced during V-gene rearrangement came from the clustering of mutations...
Topics
- Animals
- DNA
- Hybridomas
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL