Article
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
Nature - 1 Jan 2000
O'Brien R L, Brinster R L, Storb U
Abstract excerpt
Initial studies of somatically acquired mutations in immunoglobulin V regions from hybridomas and myelomas that are not derived from joining aberrations, suggested a controlled and specific hypermutation process, because spontaneous mutation rates observed for other genes are extremely low. Some evidence for the idea that mutations are introduced during V-gene rearrangement came from the clustering of mutations...
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