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Article

Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease.

The Journal of biological chemistry - 30 Jan 2009

Maki Richard A, Tyurin Vladimir A, Lyon Robert C, Hamilton Ronald L, DeKosky Steven T, Kagan Valerian E, Reynolds Wanda F

Abstract excerpt

Myeloperoxidase (MPO) is expressed in Alzheimer disease (AD) but not normal aged brain. A functional -463G/A MPO promoter polymorphism has been associated with AD risk through as yet unidentified mechanisms. Here we report that human MPO-463G allele, but not MPO-463A or mouse MPO, is strongly expressed in astrocytes and deposited in plaques in huMPO transgenic mice crossed to the APP23 model. MPO is similarly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Electrospray Ionization

Source

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Identifiers

PMID: 19059911
DOI: 10.1074/jbc.M807731200
PMCID: PMC2631957

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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