Article
Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease.
Experimental neurology - 1 Jan 1999
Reynolds W F, Rhees J, Maciejewski D, Paladino T, Sieburg H, Maki R A, Masliah E
Abstract excerpt
Myeloperoxidase (MPO) is a myeloid-specific enzyme that generates hypochlorous acid and other reactive oxygen species. MPO is present at high levels in circulating neutrophils and monocytes but is not detectable in microglia, brain-specific macrophages, in normal brain tissue. However, an earlier...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Apolipoprotein E4
- Apolipoproteins E
- Cells, Cultured
- Female
- Gene Expression
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Microglia
- Middle Aged
- Peroxidase