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Article

Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males.

Journal of lipid research - 1 Jul 2006

Castellani Lawrence W, Chang James J, Wang Xuping, Lusis Aldons J, Reynolds Wanda F

Abstract excerpt

Myeloperoxidase (MPO) is an oxidant-generating enzyme present in macrophages at atherosclerotic lesions and implicated in coronary artery disease (CAD). Although mouse models are important for investigating the role of MPO in atherosclerosis, neither mouse MPO nor its oxidation products are detected in lesions in murine models. To circumvent this problem, we generated transgenic mice expressing two functionally...

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Source

Identifiers

PMID: 16639078
DOI: 10.1194/jlr.M600005-JLR200

Genes

MPO
LDLR
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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