Article
Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis.
Free radical biology & medicine - 1 Jan 2022
Xiong Luyang, McCoy Michael, Komuro Hitoshi, West Xiaoxia Z, Yakubenko Valentin, Gao Detao, Dudiki Tejasvi, Milo Amanda, Chen Jacqueline, Podrez Eugene A, Trapp Bruce, Byzova Tatiana V
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor prognosis and no cure. Substantial evidence implicates inflammation and associated oxidative stress as a potential mechanism for ALS, especially in patients carrying the SOD1 mutation and, therefore, lacking anti-oxidant defense. The brain is particularly vulnerable to oxidation due to the abundance of polyunsaturated fatty...
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