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Article

Myeloperoxidase polymorphism and cognitive decline in older adults in the Health, Aging, and Body Composition Study.

American journal of epidemiology - 15 Jun 2006

Pope Sandra K, Kritchevsky Stephen B, Ambrosone Christine, Yaffe Kristine, Tylavsky Frances, Simonsick Eleanor M, Rosano Caterina, Stewart Scott, Harris Tamara

Abstract excerpt

Myeloperoxidase, an antimicrobial enzyme, produces oxidative free radicals. Rarely found in normal brain tissue, myeloperoxidase has been detected in microglia associated with Alzheimer's disease plaques. The authors examined a G-463A polymorphism in the promoter region of the myeloperoxidase gene (MPO) to determine the relation of MPO variants to cognitive decline over 4 years in a cohort of adults, aged 70-79...

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Source

Identifiers

PMID: 16641309
DOI: 10.1093/aje/kwj146

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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