Article
Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis.
Journal of neuroimmunology - 1 Sept 1997
Nagra R M, Becher B, Tourtellotte W W, Antel J P, Gold D, Paladino T, Smith R A, Nelson J R, Reynolds W F
Abstract excerpt
The myeloperoxidase enzyme (MPO) is expressed specifically in myeloid cells and catalyzes the formation of hypochlorous acid and other cytotoxic oxidants. We previously reported that two alleles of MPO exist which differ in promoter strength due to a base difference in an Alu-encoded hormone response element. The present study shows that the higher expressing MPO genotype is overrepresented in early onset...
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