Article
Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.
Archives of neurology - 1 Mar 2004
Zappia Mario, Manna Ida, Serra Paolo, Cittadella Rita, Andreoli Virginia, La Russa Antonella, Annesi Fernanda, Spadafora Patrizia, Romeo Nelide, Nicoletti Giuseppe, Messina Demetrio, Gambardella Antonio, Quattrone Aldo
Abstract excerpt
BACKGROUND: The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition. Two polymorphic sites in these genes (MPO-G/A and A2M-Ile/Val) have been associated with Alzheimer disease (AD), but conflicting findings have been reported in populations with different ethnic backgrounds. OBJECTIVES: To study the association of MPO-G/A and...
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