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Article

Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.

Archives of neurology - 1 Mar 2004

Zappia Mario, Manna Ida, Serra Paolo, Cittadella Rita, Andreoli Virginia, La Russa Antonella, Annesi Fernanda, Spadafora Patrizia, Romeo Nelide, Nicoletti Giuseppe, Messina Demetrio, Gambardella Antonio, Quattrone Aldo

Abstract excerpt

BACKGROUND: The genes encoding myeloperoxidase (MPO) and alpha(2)-macroglobulin (A2M) are involved in molecular pathways leading to beta-amyloid deposition. Two polymorphic sites in these genes (MPO-G/A and A2M-Ile/Val) have been associated with Alzheimer disease (AD), but conflicting findings ha...

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Source

Identifiers

PMID: 15023809
DOI: 10.1001/archneur.61.3.341

Genes

MPO
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15023809-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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