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Article

High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2009

Schneider Marlon R, Mayer-Roenne Bettina, Dahlhoff Maik, Proell Verena, Weber Karin, Wolf Eckhard, Erben Reinhold G

Abstract excerpt

Signaling through the epidermal growth factor receptor (EGFR) by ligands such as epidermal growth factor (EGF), transforming growth factor alpha (TGFA), and amphiregulin (AREG) has been reported to have effects on skeletal growth. The role of betacellulin (BTC), another EGFR ligand, in skeletal development and bone metabolism is unknown. In previous experiments, transgenic mice overexpressing BTC ubiquitously...

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Source

Identifiers

PMID: 19049329
DOI: 10.1359/jbmr.081202

Genes

BTC
EGFR
AREG
EGF
TGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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