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Article

Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2011

Zhang Xianrong, Tamasi Joseph, Lu Xin, Zhu Ji, Chen Haiyan, Tian Xiaoyan, Lee Tang-Cheng, Threadgill David W, Kream Barbara E, Kang Yibin, Partridge Nicola C, Qin Ling

Abstract excerpt

While the epidermal growth factor receptor (EGFR)-mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has been poorly defined. To address its in vivo role, we constructed transgenic and pharmacologic mouse models and used peripheral quantitative computed tomography (pQCT),...

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Identifiers

PMID: 21542005
DOI: 10.1002/jbmr.295
PMCID: PMC3179301

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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