Article
Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals.
Endocrinology - 1 Jul 2004
Wiren Kristine M, Zhang Xiao-Wei, Toombs Amber R, Kasparcova Viera, Gentile Michael A, Harada Shun-ichi, Jepsen Karl J
Abstract excerpt
The androgen receptor (AR), as a classic steroid receptor, generally mediates biologic responses to androgens. In bone tissue, both AR and the estrogen receptor (ER) are expressed in a variety of cell types. Because androgens can be converted into estrogen via aromatase activity, the specific role of the AR in maintenance of skeletal homoeostasis remains controversial. The goal of this study was to use skeletally...
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