Article
TIEG-null mice display an osteopenic gender-specific phenotype.
Bone - 1 Jun 2008
Hawse J R, Iwaniec U T, Bensamoun S F, Monroe D G, Peters K D, Ilharreborde B, Rajamannan N M, Oursler M J, Turner R T, Spelsberg T C, Subramaniam M
Abstract excerpt
TGFbeta inducible early gene-1 (TIEG) was originally cloned from human osteoblasts (OB) and has been shown to play an important role in TGFbeta/Smad signaling, regulation of gene expression and OB growth and differentiation. To better understand the biological role of TIEG in the skeleton, we have generated congenic TIEG-null (TIEG(-/-)) mice in a pure C57BL/6 background. Through the use of DXA and pQCT analysis,...
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