Article
Skeletal phenotype of growing transgenic mice that express a function-perturbing form of beta1 integrin in osteoblasts.
Calcified tissue international - 1 Jan 2005
Globus R K, Amblard D, Nishimura Y, Iwaniec U T, Kim J-B, Almeida E A C, Damsky C D, Wronski T J, van der Meulen M C H
Abstract excerpt
Skeletal modeling entails the deposition of large amounts of extracellular matrix (ECM) to form structures tailored to withstand increasing mechanical loads during rapid growth. Specific ECM molecules bind to integrin receptors on the cell surface, thereby triggering a cascade of signaling events that affect critical cell functions. To evaluate the role of integrins during skeletal growth, transgenic mice were...
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