Article
Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual.
Transgenic research - 1 Aug 2012
Davey Rachel A, Clarke Michele V, Sastra Stephen, Skinner Jarrod P, Chiang Cherie, Anderson Paul H, Zajac Jeffrey D
Abstract excerpt
Conditional gene inactivation using the Cre/loxP system has lead to significant advances in our understanding of the function of genes in a wide range of disciplines. It is becoming increasingly apparent in the literature, that Cre transgenic mice may themselves have a phenotype. In the following study we describe the bone phenotype of a commonly used Cre transgenic mouse line to study osteoblasts, the...
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