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Article

Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.

Journal of cellular physiology - 1 Jul 2020

Gingery Anne, Subramaniam Malayannan, Pitel Kevin S, Li Xiaodong, Ke Hua Z, Turner Russell T, Iwaniec Urszula T, Hawse John R

Abstract excerpt

Deletion of TGFβ inducible early gene-1 (TIEG) in mice results in an osteopenic phenotype that exists only in female animals. Molecular analyses on female TIEG knockout (KO) mouse bones identified increased expression of sclerostin, an effect that was confirmed at the protein level in serum. Sclerostin antibody (Scl-Ab) therapy has been shown to elicit bone beneficial effects in multiple animal model systems and...

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Identifiers

PMID: 31975377
DOI: 10.1002/jcp.29500
PMCID: PMC7359718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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