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Article

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008

Lee Jeongkyung, Saha Pradip K, Yang Qi-Heng, Lee Seunghee, Park Jung Yoon, Suh Yousin, Lee Soo-Kyung, Chan Lawrence, Roeder Robert G, Lee Jae W

Abstract excerpt

Activating signal cointegrator-2 (ASC-2), a transcriptional coactivator of multiple transcription factors that include the adipogenic factors peroxisome proliferator-activated receptor gamma (PPARgamma) and C/EBPalpha, is associated with histone H3-Lys-4-methyltransferase (H3K4MT) MLL3 or its paralogue MLL4 in a complex named ASCOM (ASC-2 complex). Indeed, ASC-2-null mouse embryonic fibroblasts (MEFs) have been...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19047629
DOI: 10.1073/pnas.0810100105
PMCID: PMC2614744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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