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Article

Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.

Molecular and cellular biology - 1 May 2003

Kim Seung-Whan, Park Keunhee, Kwak Eunyee, Choi Eunho, Lee Seunghee, Ham Jungyeob, Kang Heonjoong, Kim Jong Man, Hwang Seung Yong, Kong Young-Yun, Lee Keesook, Lee Jae Woon

Abstract excerpt

Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on...

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Identifiers

PMID: 12724417
DOI: 10.1128/MCB.23.10.3583-3592.2003
PMCID: PMC164762

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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