Article
Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype.
The Journal of biological chemistry - 3 Apr 2009
Schupp Michael, Cristancho Ana G, Lefterova Martina I, Hanniman Elyisha A, Briggs Erika R, Steger David J, Qatanani Mohammed, Curtin Joshua C, Schug Jonathan, Ochsner Scott A, McKenna Neil J, Lazar Mitchell A
Abstract excerpt
Nuclear peroxisome proliferator-activated receptor-gamma (PPARgamma) is required for adipocyte differentiation, but its role in mature adipocytes is less clear. Here, we report that knockdown of PPARgamma expression in 3T3-L1 adipocytes returned the expression of most adipocyte genes to preadipocyte levels. Consistently, down-regulated but not up-regulated genes showed strong enrichment of PPARgamma binding....
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