Article
c-Abl tyrosine kinase promotes adipocyte differentiation by targeting PPAR-gamma 2.
Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2014
Keshet Rom, Bryansker Kraitshtein Zina, Shanzer Matan, Adler Julia, Reuven Nina, Shaul Yosef
Abstract excerpt
Adipocyte differentiation, or adipogenesis, is a complex and highly regulated process. A recent proteomic analysis has predicted that the nonreceptor tyrosine kinase Abelson murine leukemia viral oncogene (c-Abl) is a putative key regulator of adipogenesis, but the underlying mechanism remained obscure. We found that c-Abl was activated during the early phase of mouse 3T3-L1 preadipocyte differentiation....
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