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Article

A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.

The Journal of biological chemistry - 21 Apr 2006

Gale Sarah E, Frolov Andrey, Han Xianlin, Bickel Perry E, Cao Li, Bowcock Anne, Schaffer Jean E, Ory Daniel S

Abstract excerpt

Mutations in the 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) gene have been identified in individuals affected with congenital generalized lipodystrophy (CGL). AGPAT2 catalyzes acylation of lysophosphatidic acid to phosphatidic acid, a precursor for both triacylglycerol (TAG) and phospholipid synthesis. Recent studies suggest that reduced AGPAT2 enzymatic activity may underlie the CGL clinical...

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Source

Identifiers

PMID: 16495223
DOI: 10.1074/jbc.M509612200

Genes

AGPAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.PMID 16495223Read ↗

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.Semantic proximity Read ↗

The Role of the AGPAT2 Gene in Adipose Tissue Biology and Congenital Generalized Lipodystrophy PathophysiologySemantic proximity Read ↗

Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy.Semantic proximity Read ↗

AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.Semantic proximity Read ↗

Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways.Semantic proximity Read ↗

Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.Semantic proximity Read ↗

Genetic basis of congenital generalized lipodystrophy.Semantic proximity Read ↗

Loss of adipocyte phospholipase gene <i>PLAAT3</i> causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPAR <i>γ</i> signalingSemantic proximity Read ↗

Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.Semantic proximity Read ↗

The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte DifferentiationSemantic proximity Read ↗

The lipin family: mutations and metabolism.Semantic proximity Read ↗

Genetics of Lipodystrophy.Semantic proximity Read ↗

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