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Article

Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.

Scientific reports - 24 Feb 2020

Sim M F Michelle, Persiani Elisa, Talukder Md Mesbah Uddin, Mcilroy George D, Roumane Ahlima, Edwardson J Michael, Rochford Justin J

Abstract excerpt

Seipin deficiency causes severe congenital generalized lipodystrophy (CGL) and metabolic disease. However, how seipin regulates adipocyte development and function remains incompletely understood. We previously showed that seipin acts as a scaffold protein for AGPAT2, whose disruption also causes CGL. More recently, seipin has been reported to promote adipogenesis by directly inhibiting GPAT3, leading to the...

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Share to 1-Acylglycerol-3-Phosphate O-Acyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32094408
DOI: 10.1038/s41598-020-59982-5
PMCID: PMC7039881

Genes

GPAT3
AGPAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.PMID 32094408Read ↗

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