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Article

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

Proceedings of the National Academy of Sciences of the United States of America - 17 Oct 2006

Lee Seunghee, Lee Dong-Kee, Dou Yali, Lee Jeongkyung, Lee Bora, Kwak Eunyee, Kong Young-Yun, Lee Soo-Kyung, Roeder Robert G, Lee Jae W

Abstract excerpt

Activating signal cointegrator-2 (ASC-2), a coactivator of multiple transcription factors that include retinoic acid receptor (RAR), associates with histone H3-K4 methyltranferases (H3K4MTs) MLL3 and MLL4 in mixed-lineage leukemia. Here, we show that mice expressing a SET domain mutant of MLL3 share phenotypes with isogenic ASC2+/- mice and that expression and H3-K4 trimethylation of RAR target gene RAR-beta2 are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17021013
DOI: 10.1073/pnas.0607313103
PMCID: PMC1622834

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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