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Article

Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.

Nature communications - 4 May 2018

Zhuang Lenan, Jang Younghoon, Park Young-Kwon, Lee Ji-Eun, Jain Shalini, Froimchuk Eugene, Broun Aaron, Liu Chengyu, Gavrilova Oksana, Ge Kai

Abstract excerpt

The epigenetic mechanisms regulating adipose tissue development and function are poorly understood. In this study, we show that depletion of histone H3K36 methylation by H3.3K36M in preadipocytes inhibits adipogenesis by increasing H3K27me3 to prevent the induction of C/EBPα and other targets of the master adipogenic transcription factor peroxisome proliferator-activated receptor-γ (PPARγ). Depleting H3K36...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29728617
DOI: 10.1038/s41467-018-04127-6
PMCID: PMC5935725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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