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Article

Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.

Molecular and cellular biology - 1 Jun 2008

Sue Nancy, Jack Briony H A, Eaton Sally A, Pearson Richard C M, Funnell Alister P W, Turner Jeremy, Czolij Robert, Denyer Gareth, Bao Shisan, Molero-Navajas Juan Carlos, Perkins Andrew, Fujiwara Yuko, Orkin Stuart H, Bell-Anderson Kim, Crossley Merlin

Abstract excerpt

Krüppel-like factors (KLFs) recognize CACCC and GC-rich sequences in gene regulatory elements. Here, we describe the disruption of the murine basic Krüppel-like factor gene (Bklf or Klf3). Klf3 knockout mice have less white adipose tissue, and their fat pads contain smaller and fewer cells. Adipocyte differentiation is altered in murine embryonic fibroblasts from Klf3 knockouts. Klf3 expression was studied in the...

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Identifiers

PMID: 18391014
DOI: 10.1128/MCB.01942-07
PMCID: PMC2423134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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