Article

Poxvirus K3 Orthologs Regulate NF-kB-Dependent Inflammatory Responses by Targeting the PKR–eIF2a Axis in Multiple Species

2025-06-10

Abstract excerpt

Protein kinase R (PKR) is an interferon (IFN)-inducible antiviral factor, which inhibits general mRNA translation by phosphorylating the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2). PKR also regulates NF-kB activity after virus infection; however, PKR-mediated NF-kB responses across species and their modulation by viral inhibitors remain largely unexplored. We have previously shown that...

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Literature Corpus work: 963e54ce-25c1-574a-81a8-492090dac0ed
DOI: 10.20944/preprints202506.0839.v1

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