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Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions

23 Nov 2022

Abstract excerpt

Several bat species act as asymptomatic reservoirs for many viruses that are highly pathogenic in other mammals. Here, we have characterized the functional diversification of the protein kinase R (PKR), a major antiviral innate defense system. Our data indicate that PKR has evolved under positive selection and has undergone repeated genomic duplications in bats in contrast to all studied mammals that have a...

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PMID: 36417524
DOI: 10.1126/sciadv.add7540

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