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Article

JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia.

Cardiovascular research - 1 Mar 2009

Peng Tianqing, Zhang Ting, Lu Xiangru, Feng Qingping

Abstract excerpt

AIMS: Myocardial tumour necrosis factor-alpha (TNF-alpha) production plays an important role in cardiac dysfunction during sepsis. The aim of this study was to investigate the role of c-Jun NH2-terminal kinases (JNK) signalling in cardiomyocyte TNF-alpha expression during lipopolysaccharide (LPS) stimulation and myocardial function in endotoxaemic mice. METHODS AND RESULTS: In cultured neonatal mouse...

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Source

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PMID: 19043087
DOI: 10.1093/cvr/cvn336

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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