Article
c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection.
Infection and immunity - 1 Mar 2007
Maruyama Kenta, Sano Gen-Ichiro, Ray Neelanjan, Takada Yasunari, Matsuo Koichi
Abstract excerpt
c-Fos is a component of transcription factor AP-1. We show that macrophages lacking c-Fos exhibit enhanced production of proinflammatory cytokines, potentiated NF-kappaB phosphorylation, and increased cell death following Salmonella enterica serovar Typhimurium infection. Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice.
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