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Article

Hepatic preconditioning using lipopolysaccharide: association with specific negative regulators of the Toll-like receptor 4 signaling pathway.

Transplantation - 27 May 2011

Sano Takanori, Izuishi Kunihiko, Hossain Mohammad A, Inoue Tatsushi, Kakinoki Keitaro, Hagiike Masanobu, Okano Keiichi, Masaki Tsutomu, Suzuki Yasuyuki

Abstract excerpt

BACKGROUND: Preconditioning using lipopolysaccharide (LPS), a Toll-like receptor (TLR)-4 ligand, has been demonstrated to attenuate ischemia-reperfusion injury (IRI) in several organs but has not been sufficiently elucidated in the liver. We investigated the molecular mechanism of protection induced by LPS preconditioning against hepatic IRI. METHODS: BALB/c mice underwent 70% hepatic ischemia for 90 min. LPS was...

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Identifiers

PMID: 21403587
DOI: 10.1097/TP.0b013e31821457cb

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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