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Article

JNK1 is required to preserve cardiac function in the early response to pressure overload.

Biochemical and biophysical research communications - 19 May 2006

Tachibana Hideo, Perrino Cinzia, Takaoka Hideyuki, Davis Roger J, Naga Prasad Sathyamangla V, Rockman Howard A

Abstract excerpt

Cardiac stress consistently activates c-Jun NH(2)-terminal kinase (JNK) pathways, however the role of different members of the JNK family is unclear. In this study, we applied pressure overload (TAC) in mice with selective deletion of the three JNK genes (Jnk1(-/-), Jnk2(-/-), and Jnk3(-/-)). Following TAC, all three JNK knockout mouse lines developed cardiac hypertrophy similar to wild-type mice (WT), but only...

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Identifiers

PMID: 16579967
DOI: 10.1016/j.bbrc.2006.03.065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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