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Article

Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia.

Journal of cellular and molecular medicine - 1 Aug 2009

Zhao Peng, Wang Jingying, He Leilei, Ma Heng, Zhang Xiaoyu, Zhu Xinglei, Dolence E Kurt, Ren Jun, Li Ji

Abstract excerpt

Toll-like receptor 4 (TLR4), a proximal signalling receptor in innate immune responses to lipopolysaccharide of gram-negative pathogens, is expressed in the heart. Accumulating evidence have consolidated the notion that TLR4 plays an essential role in the pathogenesis of cardiac dysfunction. However, the molecular mechanisms of TLR4 responsible for ischemia-induced cardiac dysfunction remain unclear. To address...

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Source

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Identifiers

PMID: 19508385
DOI: 10.1111/j.1582-4934.2009.00798.x
PMCID: PMC3828863

Genes

TLR4

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