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Article

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Babaev Vladimir R, Yeung Michele, Erbay Ebru, Ding Lei, Zhang Youmin, May James M, Fazio Sergio, Hotamisligil Gökhan S, Linton MacRae F

Abstract excerpt

OBJECTIVE: The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling. Macrophages express 2 JNK isoforms, JNK1 and JNK2, which may have different effects on cell survival and atherosclerosis. APPROACH AND RESULTS: To dissect the effect of macrophage JNK1 and JNK2 on early atherosclerosis, Ldlr(-/-) mice were reconstituted with...

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Identifiers

PMID: 27102962
DOI: 10.1161/ATVBAHA.116.307580
PMCID: PMC4882236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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