Article
Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.
Gastroenterology - 1 Feb 2009
Sugiyama Masaya, Tanaka Yasuhito, Kurbanov Fuat, Maruyama Isao, Shimada Takashi, Takahashi Satoru, Shirai Tomoyuki, Hino Keisuke, Sakaida Isao, Mizokami Masashi
Abstract excerpt
BACKGROUND & AIMS: Little is known about the direct cytopathic effect of hepatitis B virus (HBV) and its association with particular viral genotypes or genetic mutations. We investigate HBV genotype-related differences in viral replication, antigen expression, and histopathology in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mice harboring human hepatocytes. METHODS: Mice...
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