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Article

Susceptibility of different hepatitis B virus isolates to interferon-alpha in a mouse model based on hydrodynamic injection.

PloS one - 1 Jan 2014

Song Jingjiao, Zhou Yun, Li Sheng, Wang Baoju, Zheng Xin, Wu Jun, Gibbert Kathrin, Dittmer Ulf, Lu Mengji, Yang Dongliang

Abstract excerpt

Interferon alpha (IFN-α) is commonly used for the treatment of chronic hepatitis B (CHB) patients. Many factors including viral genetics may determine the outcome of IFN-α therapy. In this study, we tested whether the expression of IFN-α directly in the liver inhibits HBV gene expression and replication using a HBV hydrodynamic injection (HI) mouse model. Two replication-competent clones from different HBV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24618716
DOI: 10.1371/journal.pone.0090977
PMCID: PMC3950299

Genes

ISG15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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