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A Novel cDNA-uPA/SCID/Rag2-/-/Jak3-/- Mouse Model for Hepatitis Virus Infection and Reconstruction of Human Immune System

2021-07-20

Abstract excerpt

The humanized mouse is a widely used in vivo model for the investigation of pathogenesis and drug development. In this study, we generated new immunodeficiency cDNA-urokinase-type plasminogen activator (uPA)/SCID/Rag2 -/- /Jak3 -/- mice and established the mouse model with a humanized liver and immune system. Transplantation of human hepatocytes with human leukocyte antigen (HLA)-A24 resulted in establishment of a...

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Identifiers and source

Literature Corpus work
01343331-10ac-5e1b-be3d-bf419e9aa7d3
DOI
10.21203/rs.3.rs-712014/v1
Open publication

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