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Article

Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver.

Gastroenterology - 1 Dec 2017

Dusséaux Mathilde, Masse-Ranson Guillemette, Darche Sylvie, Ahodantin James, Li Yan, Fiquet Oriane, Beaumont Elodie, Moreau Pierrick, Rivière Lise, Neuveut Christine, Soussan Patrick, Roingeard Philippe, Kremsdorf Dina, Di Santo James P, Strick-Marchand Helene

Abstract excerpt

BACKGROUND & AIMS: Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the immune response against the virus and how it affects disease progression are unclear. METHODS: We performed studies with BALB/c Rag2-/-Il2rg-/-SirpaNODAlb-uPAtg/tg mice, stably engrafted with human hepatocytes (HUHEP) with or without a human immune system (HIS). HUHEP and HIS-HUHEP mice were given an intraperitoneal...

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Identifiers

PMID: 28851562
DOI: 10.1053/j.gastro.2017.08.034
PMCID: PMC5733397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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