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Article

Infection courses, virological features and IFN-α responses of HBV genotypes in cell culture and animal models.

Journal of hepatology - 1 Dec 2021

Zhang Min, Zhang Zhensheng, Imamura Michio, Osawa Mitsutaka, Teraoka Yuji, Piotrowski Jason, Ishida Yuji, Sozzi Vitina, Revill Peter A, Saito Takeshi, Chayama Kazuaki, Liang T Jake

Abstract excerpt

BACKGROUND & AIMS: HBV consists of 9 major genotypes (A to I), 1 minor strain (designated J) and multiple subtypes, which may be associated with different clinical characteristics. As only cell lines expressing genotype D3 have been established, herein, we aimed to establish stable cell lines producing high-titer cell culture-generated HBV (HBVcc) of different genotypes and to explore their infectivity,...

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Identifiers

PMID: 34363922
DOI: 10.1016/j.jhep.2021.07.030
PMCID: PMC8604785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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