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Article

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

12 Apr 2011

Abstract excerpt

B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1) fusion has an overall good prognosis, but relapses occur, usually after cessation of treatment and occasionally many years later. We have investigated the clonal origins of relapse by comparing the profiles of genomewide copy number alterations at presentation in 21 patients with those in matched relapse (12-119 months). We...

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PMID: 21482711
DOI: 10.1182/blood-2010-10-314674

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