Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.

doi:10.3324/haematol.2015.129692

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Article

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.

Haematologica - 1 Nov 2015

Kunz Joachim B, Rausch Tobias, Bandapalli Obul R, Eilers Juliane, Pechanska Paulina, Schuessele Stephanie, Assenov Yassen, Stütz Adrian M, Kirschner-Schwabe Renate, Hof Jana, Eckert Cornelia, von Stackelberg Arend, Schrappe Martin, Stanulla Martin, Koehler Rolf, Avigad Smadar, Elitzur Sarah, Handgretinger Rupert, Benes Vladimir, Weischenfeldt Joachim, Korbel Jan O, Muckenthaler Martina U, Kulozik Andreas E

Abstract excerpt

Relapsed precursor T-cell acute lymphoblastic leukemia is characterized by resistance against chemotherapy and is frequently fatal. We aimed at understanding the molecular mechanisms resulting in relapse of T-cell acute lymphoblastic leukemia and analyzed 13 patients at first diagnosis, remission and relapse by whole exome sequencing, targeted ultra-deep sequencing, multiplex ligation dependent probe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26294725
DOI: 10.3324/haematol.2015.129692
PMCID: PMC4825305

Genes

SMARCA4
SUZ12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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