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Article

Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation.

Oncotarget - 19 Jan 2016

Xiao Haowen, Wang Li-Mengmeng, Luo Yi, Lai Xiaoyu, Li Caihua, Shi Jimin, Tan Yamin, Fu Shan, Wang Yebo, Zhu Ni, He Jingsong, Zheng Weiyan, Yu Xiaohong, Cai Zhen, Huang He

Abstract excerpt

Although steady improvements to chemotherapeutic treatments has helped cure 80% of childhood acute lymphoblastic leukemia (ALL) cases, chemotherapy has proven to be less effective in treating the majority of adult patients, leaving allogeneic hematopoietic stem cell transplantation (allo-HSCT) as the primary adult treatment option. Nevertheless relapse are the leading cause of death following allo-HSCT. The...

Topics

Adult
Base Sequence
Child
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
High-Throughput Nucleotide Sequencing
Humans
Mutation
Neoplasm Recurrence, Local
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Transplantation, Homologous

Source

Open in PubMed Open full text

Identifiers

PMID: 26527318
DOI: 10.18632/oncotarget.6259
PMCID: PMC4823065

Genes

CREBBP
KRAS
MYC
PTPN21
SETD2
USP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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