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Article

The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density.

Clinical pharmacology and therapeutics - 1 Mar 2009

Kang Y S, Park S Y, Yim C H, Kwak H S, Gajendrarao P, Krishnamoorthy N, Yun S-C, Lee K W, Han K O

Abstract excerpt

Osteoporosis is influenced by genetic factors. The interindividual variability in the activity of CYP3A, the metabolic enzyme of sex hormones, may result from genetic polymorphisms. In a study of 2,178 women of ages 40-79 years, the presence of the CYP3A4*18 variant was found to be significantly associated with low bone mass. In vitro functional analyses indicate that CYP3A4*18 is a gain-of-function mutation in...

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Identifiers

PMID: 19020497
DOI: 10.1038/clpt.2008.215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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