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Article

Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with body composition changes in women on aromatase inhibitors for ER (+) breast cancer.

Pharmacogenetics and genomics - 1 Aug 2015

Napoli Nicola, Rastelli Antonella, Ma Cynthia, Colleluori Georgia, Vattikuti Swapna, Armamento-Villareal Reina

Abstract excerpt

OBJECTIVE: Polymorphisms in the CYP19A1 (aromatase) gene influence disease-free survival and bone loss in patients taking aromatase inhibitors (AIs) for estrogen receptor-positive (ER+) breast cancers. Because AI use results in severe estrogen deficiency that may lead to changes in body composition, the aim of this study was to determine the effect of the rs700518 polymorphism in the CYP19A1 gene on the changes...

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Identifiers

PMID: 26049585
DOI: 10.1097/FPC.0000000000000146
PMCID: PMC4498982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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