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Article

Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene.

Journal of translational medicine - 25 Apr 2012

Trdan Lušin Tina, Stieger Bruno, Marc Janja, Mrhar Aleš, Trontelj Jurij, Zavratnik Andrej, Ostanek Barbara

Abstract excerpt

BACKGROUND: Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics. The aim of this study was to determine the role of organic-anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants in the pharmacokinetics and pharmacodynamics of raloxifene. METHODS: To test the role of OATP1B1 and...

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Identifiers

PMID: 22533838
DOI: 10.1186/1479-5876-10-76
PMCID: PMC3476964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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