Article
Polymorphisms in the CYP19 gene that influence bone mineral density.
Pharmacogenomics - 1 Apr 2007
Riancho José A
Abstract excerpt
Osteoporosis is a prevalent disease with a strong genetic component. Estrogens play a critical role in bone homeostasis. The aromatization of androgenic precursors is the main source of estrogens in men and postmenopausal women. Thus, aromatase is an attractive osteoporosis candidate gene. In this paper the influence of aromatase activity and aromatase gene variants on skeletal homeostasis is reviewed. The...
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