Article
Polymorphisms in the P450 c17 (17-hydroxylase/17,20-Lyase) and P450 c19 (aromatase) genes: association with serum sex steroid concentrations and bone mineral density in postmenopausal women.
The Journal of clinical endocrinology and metabolism - 1 Jan 2004
Somner John, McLellan Susan, Cheung Joseph, Mak Y T, Frost Michelle L, Knapp Karen M, Wierzbicki Anthony S, Wheeler Michael, Fogelman Ignac, Ralston Stuart H, Hampson Geeta N
Abstract excerpt
The CYP 17 and CYP 19 genes encode 17alpha-hydroxylase/17,20-lyase and aromatase, respectively, both involved in sex hormone synthesis. We investigated the association between 2 common polymorphisms in 1) the promoter region (T-->C substitution) of CYP 17, and 2) exon 3 (G-->A) of CYP 19, bone mi...
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