Article
A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism.
The Journal of clinical endocrinology and metabolism - 1 Jun 2004
Gennari Luigi, Masi Laura, Merlotti Daniela, Picariello Lucia, Falchetti Alberto, Tanini Annalisa, Mavilia Carmelo, Del Monte Francesca, Gonnelli Stefano, Lucani Barbara, Gennari Carlo, Brandi Maria Luisa
Abstract excerpt
Current evidence suggests that estrogen plays a dominant role in determining bone mineral density (BMD) in men, and inactivating mutations in the aromatase CYP19 gene have been associated with low bone mass in young males. We previously reported an association between a TTTA repeat polymorphism in intron 4 of the CYP19 gene and osteoporotic risk in postmenopausal females. Here we explore the role of this...
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