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Article

Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer.

Bone - 1 Aug 2013

Napoli Nicola, Rastelli Antonella, Ma Cynthia, Yarramaneni Jayasree, Vattikutti Swapna, Moskowitz Gerard, Giri Tusar, Mueller Cheryl, Kulkarny Vibhati, Qualls Clifford, Ellis Matthew, Armamento-Villareal Reina

Abstract excerpt

PURPOSE: Polymorphisms in the CYP19A1 (aromatase) gene have been reported to influence disease-free survival and the incidence of musculoskeletal complaints in patients taking aromatase inhibitors (AIs) for estrogen receptor positive (ER+) breast cancer. Bone loss and fractures are well-recognized complications from AI therapy. The objective of this study is to determine the influence of polymorphisms in the...

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Identifiers

PMID: 23643682
DOI: 10.1016/j.bone.2013.04.021
PMCID: PMC3966714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer.PMID 23643682Read ↗

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