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A translocation-competent pore is required for <i>Shigella flexneri</i> to escape from the double membrane vacuole during intercellular spread

2024-11-11

Abstract excerpt

<h4>ABSTRACT</h4> Type 3 secretion systems (T3SSs) enable bacterial virulence by translocating virulence proteins (effectors) into host cells. Shigella flexneri require T3SS to invade and to spread between cells in the colon. In order to spread, S. flexneri forms membrane protrusions that push into the adjacent host cell. These protrusions are resolved into double membrane vacuoles (DMVs) that the bacteria quic...

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Literature Corpus work
dbeb5862-f5b1-5e08-9f94-f543744e8cc1
DOI
10.1101/2024.11.11.623084
Open publication

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